InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dmbx1

Summary

InnateDB Protein

IDBP-176987.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmbx1

Protein Name

diencephalon/mesencephalon homeobox 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081366

InnateDB Gene

IDBG-176985 (Dmbx1)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability. {ECO:0000269PubMed:11914943, ECO:0000269PubMed:12055180, ECO:0000269PubMed:15314164, ECO:0000269PubMed:15890343}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:O35137, ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000255PROSITE- ProRule:PRU00138}.

Disease Associations

Tissue Specificity

Expressed in adult brain, stomach, and testis. Expressed in the developing diencephalon, midbrain and hindbrain. During limb development, expressed in a temporal pattern with expression being first restricted to the forelimbs and then subsequently to the hindlimbs. {ECO:0000269PubMed:11744391, ECO:0000269PubMed:11914943, ECO:0000269PubMed:12111214, ECO:0000269PubMed:12175514}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0007420	brain development
GO:0008343	adult feeding behavior
GO:0008344	adult locomotory behavior
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048589	developmental growth