InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkx2-6

Summary

InnateDB Protein

IDBP-177071.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkx2-6

Protein Name

NK2 transcription factor related, locus 6 (Drosophila)

Synonyms

AV044928; Nkx-2.6; Nkx2.6; tinman; Tix;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049898

InnateDB Gene

IDBG-177069 (Nkx2-6)

Protein Structure

UniProt Annotation

Function

In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. {ECO:0000269PubMed:10733590, ECO:0000269PubMed:11390666}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Not detected in any neonate or adult tissues. {ECO:0000269PubMed:10733590}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0021854	hypothalamus development
GO:0030154	cell differentiation
GO:0035050	embryonic heart tube development
GO:0043066	negative regulation of apoptotic process
GO:0043586	tongue development
GO:0048565	digestive tract development
GO:0055014	atrial cardiac muscle cell development
GO:0055015	ventricular cardiac muscle cell development
GO:0060037	pharyngeal system development
GO:0060039	pericardium development