InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Faah

Summary

InnateDB Protein

IDBP-177091.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Faah

Protein Name

fatty acid amide hydrolase

Synonyms

AW412498;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041543

InnateDB Gene

IDBG-177087 (Faah)

Protein Structure

UniProt Annotation

Function

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0017064	fatty acid amide hydrolase activity
GO:0047372	acylglycerol lipase activity