InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zbtb7a

Summary

InnateDB Protein

IDBP-177094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zbtb7a

Protein Name

zinc finger and BTB domain containing 7a

Synonyms

9030619K07Rik; 9130006G12Rik; AI452336; FBI-1; Lrf; Pokemon; Zbtb7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047333

InnateDB Gene

IDBG-177092 (Zbtb7a)

Protein Structure

UniProt Annotation

Function

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'. {ECO:0000269PubMed:15662416}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15662416, ECO:0000269PubMed:9927193}.

Disease Associations

Tissue Specificity

Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In the spleen, mainly expressed in the white pulp germinal centers (at protein level). Up-regulated in thymic lymphomas. {ECO:0000269PubMed:15662416, ECO:0000269PubMed:9927193}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030154	cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051216	cartilage development