InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde6d

Summary

InnateDB Protein

IDBP-177113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde6d

Protein Name

phosphodiesterase 6D, cGMP-specific, rod, delta

Synonyms

AI841218; PrBP/delta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027444

InnateDB Gene

IDBG-177111 (Pde6d)

Protein Structure

UniProt Annotation

Function

Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation. {ECO:0000269PubMed:10518933, ECO:0000269PubMed:15979089}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007601	visual perception
GO:0007602	phototransduction
GO:0008152	metabolic process
GO:0033124	regulation of GTP catabolic process
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005829	cytosol
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

MGI:1270843

InterPro

IPR008015 GMP phosphodiesterase, delta subunit
IPR014756 Immunoglobulin E-set
IPR017287 Retinal rod rhodopsin-sensitive cGMP 3\', 5\'-cyclic phosphodiesterase, delta subunit

PFAM

PF05351

PRINTS

PIRSF

PIRSF037825

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O55057