Version 5.4
Homo sapiens Protein: ASB2
Summary
InnateDB Protein IDBP-17714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB2
Protein Name ankyrin repeat and SOCS box containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000320675
InnateDB Gene IDBG-17712 (ASB2)
Protein Structure
UniProt Annotation
Function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:15590664, ECO:0000269PubMed:16325183}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001496 SOCS protein, C-terminal
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF07525
PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00253
SM00969
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96Q27
PhosphoSite PhosphoSite-Q96Q27
TrEMBL G3V484
UniProt Splice Variant
Entrez Gene 51676
UniGene Hs.683678
RefSeq NP_057234
HUGO HGNC:16012
OMIM 605759
CCDS CCDS9915
HPRD 05768
IMGT
EMBL AB056723 AB488462 AF159164 AJ251238 AK303686 AK315628 AL079302 AL132642 AL137735 BC032354 CH471061
GenPept AAD45345 AAH32354 BAB64532 BAG37996 BAG64678 BAI77868 CAB70899 CAC17765 EAW81540 EAW81542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca