InnateDB Protein
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IDBP-177217.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dis3l2
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Protein Name
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DIS3 mitotic control homolog (S. cerevisiae)-like 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000070506
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InnateDB Gene
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IDBG-177215 (Dis3l2)
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Protein Structure
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Function |
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255HAMAP-Rule:MF_03045, ECO:0000269PubMed:23594738}.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03045, ECO:0000269PubMed:23594738}. Cytoplasm, P-body {ECO:0000255HAMAP-Rule:MF_03045}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0000291
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nuclear-transcribed mRNA catabolic process, exonucleolytic
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GO:0007067
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mitotic nuclear division
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GO:0008285
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negative regulation of cell proliferation
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GO:0010587
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miRNA catabolic process
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GO:0019827
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stem cell maintenance
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GO:0034427
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nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
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GO:0051306
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mitotic sister chromatid separation
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GO:0090501
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RNA phosphodiester bond hydrolysis
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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GO:1990074
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polyuridylation-dependent mRNA catabolic process
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Cellular Component |
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PDB ID |
MGI:2442555
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CI75
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PhosphoSite |
PhosphoSite-Q8CI75
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
208718
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UniGene |
Mm.486643
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RefSeq |
NP_705758
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MGI ID |
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MGI Symbol |
Dis3l2
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OMIM |
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CCDS |
CCDS15124
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HPRD |
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IMGT |
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EMBL |
AK031180
BC036177
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GenPept |
AAH36177
BAC27292
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