InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APBA3

Summary

InnateDB Protein

IDBP-17725.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APBA3

Protein Name

amyloid beta (A4) precursor protein-binding, family A, member 3

Synonyms

MGC:15815; mint3; X11L2;

Species

Homo sapiens

Ensembl Protein

ENSP00000315136

InnateDB Gene

IDBG-17723 (APBA3)

Protein Structure

UniProt Annotation

Function

May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. {ECO:0000269PubMed:19726677}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:19726677}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined with lower levels in brain and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007268	synaptic transmission
GO:0010468	regulation of gene expression
GO:0015031	protein transport
GO:0043086	negative regulation of catalytic activity