InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Utp3

Summary

InnateDB Protein

IDBP-177254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Utp3

Protein Name

UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)

Synonyms

2400011K09Rik; AW557551; C87704; Crl1; Crlz1; Sas10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087896

InnateDB Gene

IDBG-177252 (Utp3)

Protein Structure

UniProt Annotation

Function

Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain. {ECO:0000250UniProtKB:Q12136, ECO:0000269PubMed:11404095}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11404095}.

Disease Associations

Tissue Specificity

Detected mainly in subsets of neuronal cells of the brain. In the 17.5 dpc embryo, mainly expressed in the olfactory bulb and cerebral cortex. Postnatally, additionally expressed in the cerebellar cortex, most strongly in the hippocampus. {ECO:0000269PubMed:11404095}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007420	brain development
GO:0016568	chromatin modification

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

MGI:1919230

InterPro

IPR007146 Sas10/Utp3/C1D
IPR018972 Sas10 C-terminal domain

PFAM

PF04000
PF09368

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JI13

PhosphoSite

PhosphoSite-Q9JI13

TrEMBL

UniProt Splice Variant

Entrez Gene

65961

UniGene

Mm.88546

RefSeq

NP_075541

MGI ID

MGI Symbol

Utp3

OMIM

CCDS

CCDS19402

HPRD

IMGT

EMBL

AF155362 AF271213 AK010316 AK145637 BC022994

GenPept

AAF80256 AAF91409 AAH22994 BAB26848 BAE26555