InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nsun4

Summary

InnateDB Protein

IDBP-177272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nsun4

Protein Name

NOL1/NOP2/Sun domain family, member 4

Synonyms

2310010O12Rik; 2810405F18Rik; AI507900; Shtap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030475

InnateDB Gene

IDBG-177270 (Nsun4)

Protein Structure

UniProt Annotation

Function

Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA at position 911; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. {ECO:0000269PubMed:24516400}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:21531335}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003723	RNA binding
GO:0008168	methyltransferase activity

Biological Process

GO:0006364	rRNA processing
GO:0008150	biological_process
GO:0032259	methylation

Cellular Component

GO:0005739	mitochondrion
GO:0005762	mitochondrial large ribosomal subunit

Protein Structure and Domains

PDB ID

MGI:1919431

InterPro

IPR001678 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p
IPR023267 RNA (C5-cytosine) methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01189

PRINTS

PR02008

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CZ57