InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nsun4

Summary

InnateDB Protein

IDBP-177274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nsun4

Protein Name

NOL1/NOP2/Sun domain family, member 4

Synonyms

2310010O12Rik; 2810405F18Rik; AI507900; Shtap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030474

InnateDB Gene

IDBG-177270 (Nsun4)

Protein Structure

UniProt Annotation

Function

Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA at position 911; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. {ECO:0000269PubMed:24516400}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:21531335}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003723	RNA binding
GO:0008168	methyltransferase activity

Biological Process

GO:0006364	rRNA processing
GO:0008150	biological_process
GO:0032259	methylation

Cellular Component

GO:0005739	mitochondrion
GO:0005762	mitochondrial large ribosomal subunit

Protein Structure and Domains

PDB ID

MGI:1919431

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CZ57

PhosphoSite

PhosphoSite-Q9CZ57

TrEMBL

UniProt Splice Variant

Entrez Gene

72181

UniGene

Mm.474929

RefSeq

MGI ID

MGI Symbol

Nsun4

OMIM

CCDS

HPRD

IMGT

EMBL

AK009285 AK012994 AL627105 BC024628

GenPept

AAH24628 BAB26195 BAB28584 CAM22670 CAM22671