InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nmrk2

Summary

InnateDB Protein

IDBP-177302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nmrk2

Protein Name

integrin beta 1 binding protein 3

Synonyms

2310015C21Rik; Itgb1bp3; Mibp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005069

InnateDB Gene

IDBG-177300 (Nmrk2)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in skeletal muscle (at protein level). {ECO:0000269PubMed:10613898}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0050262	ribosylnicotinamide kinase activity

Biological Process

GO:0009435	NAD biosynthetic process
GO:0016310	phosphorylation
GO:0045662	negative regulation of myoblast differentiation

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

MGI:1916814

InterPro

IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D7C9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

69564

UniGene

Mm.437211

RefSeq

NP_081396

MGI ID

MGI Symbol

Nmrk2

OMIM

CCDS

CCDS24046

HPRD

IMGT

EMBL

AK009352 AK137483 BC119244 BC119246

GenPept

AAI19245 AAI19247 BAB26235 BAE23375