Version 5.4
Mus musculus Protein: Tectb
Summary
InnateDB Protein IDBP-177317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tectb
Protein Name tectorin beta
Synonyms Tctnb;
Species Mus musculus
Ensembl Protein ENSMUSP00000025936
InnateDB Gene IDBG-177315 (Tectb)
Protein Structure
UniProt Annotation
Function One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
Biological Process
GO:0007605 sensory perception of sound
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:109574
InterPro IPR001507 Zona pellucida domain
PFAM PF00100
PRINTS PR00023
PIRSF
SMART SM00241
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08524
PhosphoSite PhosphoSite-
TrEMBL Q1HL20
UniProt Splice Variant
Entrez Gene 21684
UniGene Mm.488510
RefSeq NP_033374
MGI ID
MGI Symbol Tectb
OMIM
CCDS CCDS29907
HPRD
IMGT
EMBL AC110206 BC138888 BC138889 CH466585 DQ479930 X99806
GenPept AAI38889 AAI38890 ABF48509 CAA68139 EDL01721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca