InnateDB Protein
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IDBP-177320.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Klk14
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Protein Name
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kallikrein related-peptidase 14
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000056935
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InnateDB Gene
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IDBG-177318 (Klk14)
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Protein Structure
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Function |
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2447564
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InterPro |
IPR001254
Peptidase S1
IPR001314
Peptidase S1A, chymotrypsin-type
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
PR00722
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CGR5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
317653
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UniGene |
Mm.247377
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RefSeq |
NP_777355
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MGI ID |
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MGI Symbol |
Klk14
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OMIM |
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CCDS |
CCDS21180
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HPRD |
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IMGT |
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EMBL |
AY152433
BC128019
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GenPept |
AAI28020
AAN78421
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