InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Loxl2

Summary

InnateDB Protein

IDBP-177379.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Loxl2

Protein Name

lysyl oxidase-like 2

Synonyms

1110004B06Rik; 4930526G11Rik; 9430067E15Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022660

InnateDB Gene

IDBG-177377 (Loxl2)

Protein Structure

UniProt Annotation

Function

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3 (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. {ECO:0000250, ECO:0000269PubMed:21071451}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromatin (By similarity). It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest expression in skin, lung and thymus. Present in chondrocytes: mainly expressed by chondrocytes in healing fractures and in epiphyseal growth plates (at protein level). {ECO:0000269PubMed:21071451}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0004720	protein-lysine 6-oxidase activity
GO:0005044	scavenger receptor activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0035064	methylated histone binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0001666	response to hypoxia
GO:0001837	epithelial to mesenchymal transition
GO:0001935	endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006464	cellular protein modification process
GO:0006898	receptor-mediated endocytosis
GO:0016570	histone modification
GO:0018277	protein deamination
GO:0030199	collagen fibril organization
GO:0032332	positive regulation of chondrocyte differentiation
GO:0043542	endothelial cell migration
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046688	response to copper ion
GO:0055114	oxidation-reduction process