InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr2c

Summary

InnateDB Protein

IDBP-177392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr2c

Protein Name

5-hydroxytryptamine (serotonin) receptor 2C

Synonyms

5-HT2C; 5-HT2cR; 5-HTR2C; 5HT1c; Htr1c; SR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094021

InnateDB Gene

IDBG-177388 (Htr2c)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. {ECO:0000269PubMed:17451451, ECO:0000269PubMed:17596444, ECO:0000269PubMed:19038216, ECO:0000269PubMed:21037584, ECO:0000269PubMed:21048120, ECO:0000269PubMed:21835345, ECO:0000269PubMed:7700379, ECO:0000269PubMed:9771748}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in brain cortex, hypothalamus, brainstem and arcuate nucleus. Detected in the paraventricular nucleus of the hypothalamus. {ECO:0000269PubMed:17596444, ECO:0000269PubMed:19038216, ECO:0000269PubMed:7700379}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001587	Gq/11-coupled serotonin receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0008144	drug binding
GO:0051378	serotonin binding
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Biological Process

GO:0001662	behavioral fear response
GO:0006182	cGMP biosynthetic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway
GO:0007626	locomotory behavior
GO:0007631	feeding behavior
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0031644	regulation of neurological system process
GO:0032098	regulation of appetite
GO:0042493	response to drug
GO:0043397	regulation of corticotropin-releasing hormone secretion
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96281

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000377 5-Hydroxytryptamine 2C receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00517
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34968