InnateDB Protein
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IDBP-177410.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Twf1
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Protein Name
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twinfilin, actin-binding protein, homolog 1 (Drosophila)
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Synonyms
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A6; Ptk9; twinfilin;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023087
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InnateDB Gene
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IDBG-177408 (Twf1)
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Protein Structure
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Function |
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. {ECO:0000269PubMed:10669753, ECO:0000269PubMed:15282541, ECO:0000269PubMed:16511569, ECO:0000269PubMed:9249064}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10669753}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10669753}. Note=Diffuse cytoplasmic localization with perinuclear and G- actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in brain, liver and kidney. Also expressed in heart, lung and testis. Not detected in spleen or skeletal muscle. {ECO:0000269PubMed:10669753, ECO:0000269PubMed:12807912, ECO:0000269PubMed:9249064}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1100520
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InterPro |
IPR002108
Actin-depolymerising factor homology domain
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PFAM |
PF00241
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PRINTS |
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PIRSF |
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SMART |
SM00102
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TIGRFAMs |
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Modification |
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SwissProt |
Q91YR1
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PhosphoSite |
PhosphoSite-Q91YR1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
233637
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UniGene |
Mm.490250
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RefSeq |
NP_032997
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MGI ID |
3DAW
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MGI Symbol |
Twf1
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OMIM |
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CCDS |
CCDS27773
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HPRD |
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IMGT |
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EMBL |
AK147990
AK150852
AY267188
BC015081
BC094034
U82324
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GenPept |
AAB66592
AAH15081
AAH94034
AAP31404
BAE28272
BAE29908
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