InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Parp16

Summary

InnateDB Protein

IDBP-177479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Parp16

Protein Name

poly (ADP-ribose) polymerase family, member 16

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070098

InnateDB Gene

IDBG-177475 (Parp16)

Protein Structure

UniProt Annotation

Function

Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0006471	protein ADP-ribosylation
GO:0006986	response to unfolded protein
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0008152	metabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0060548	negative regulation of cell death
GO:0070213	protein auto-ADP-ribosylation
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0071782	endoplasmic reticulum tubular network