Mus musculus Protein: Ddx39b | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-177491.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ddx39b | ||||||||||||||||||||||
Protein Name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | ||||||||||||||||||||||
Synonyms | 0610030D10Rik; AI428441; Bat-1; Bat1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81Eh; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000070682 | ||||||||||||||||||||||
InnateDB Gene | IDBG-177489 (Ddx39b) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription- independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability (By similarity). {ECO:0000250}.Splice factor that is required for the first ATP- dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Can translocate to the cytoplasm in the presence of MX1. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:99240 | ||||||||||||||||||||||
InterPro |
IPR001650
Helicase, C-terminal IPR006935 Helicase/UvrB domain IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal IPR014001 Helicase, superfamily 1/2, ATP-binding domain IPR014014 RNA helicase, DEAD-box type, Q motif IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00271
PF04851 PF00270 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00490
SM00487 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9Z1N5 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9Z1N5 | ||||||||||||||||||||||
TrEMBL | G3UXI6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 53817 | ||||||||||||||||||||||
UniGene | Mm.439827 | ||||||||||||||||||||||
RefSeq | NP_062667 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Ddx39b | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS28695 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC007080 AF118128 AK051034 AK088867 AY255786 AY255787 BC011067 BC024859 CR974444 | ||||||||||||||||||||||
GenPept | AAD13115 AAD30177 AAH11067 AAH24859 AAP91685 AAP91686 BAC34505 BAC40624 | ||||||||||||||||||||||