InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Notch2

Summary

InnateDB Protein

IDBP-177581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Notch2

Protein Name

Notch gene homolog 2 (Drosophila)

Synonyms

AI853703; N2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078741

InnateDB Gene

IDBG-177579 (Notch2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0002011	morphogenesis of an epithelial sheet
GO:0002437	inflammatory response to antigenic stimulus
GO:0003184	pulmonary valve morphogenesis
GO:0006959	humoral immune response
GO:0007050	cell cycle arrest
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0016049	cell growth
GO:0030154	cell differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030513	positive regulation of BMP signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0046579	positive regulation of Ras protein signal transduction
GO:0046849	bone remodeling
GO:0050793	regulation of developmental process
GO:0060413	atrial septum morphogenesis
GO:0060674	placenta blood vessel development
GO:0061073	ciliary body morphogenesis
GO:0072602	interleukin-4 secretion

Cellular Component

GO:0005634	nucleus
GO:0005887	integral component of plasma membrane
GO:0005929	cilium
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:97364

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000800 Notch domain
IPR001881 EGF-like calcium-binding domain
IPR002110 Ankyrin repeat
IPR008297 Notch
IPR010660 Notch, NOD domain
IPR011656 Notch, NODP domain
IPR013111 EGF-like domain, extracellular
IPR020683 Ankyrin repeat-containing domain
IPR022336 Neurogenic locus Notch 2
IPR024600 Domain of unknown function DUF3454, notch

PFAM