Version 5.4
Mus musculus Protein: Cilp
Summary
InnateDB Protein IDBP-177587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cilp
Protein Name cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036631
InnateDB Gene IDBG-177585 (Cilp)
Protein Structure
UniProt Annotation
Function Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:2444507
InterPro IPR000884 Thrombospondin, type 1 repeat
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008969 Carboxypeptidase-like, regulatory domain
IPR013098 Immunoglobulin I-set
PFAM PF00090
PF07679
PRINTS
PIRSF
SMART SM00209
SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q66K08
PhosphoSite PhosphoSite-Q66K08
TrEMBL
UniProt Splice Variant
Entrez Gene 214425
UniGene Mm.138455
RefSeq NP_775561
MGI ID
MGI Symbol Cilp
OMIM
CCDS CCDS23287
HPRD
IMGT
EMBL AK081544 AY116589 AY116590 AY116591 BC080666
GenPept AAH80666 AAM92571 AAM92572 BAC38252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca