Version 5.4
Mus musculus Protein: Vti1a
Summary
InnateDB Protein IDBP-177704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vti1a
Protein Name vesicle transport through interaction with t-SNAREs homolog 1A (yeast)
Synonyms 1110014F16Rik; 1110018K19Rik; 4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2;
Species Mus musculus
Ensembl Protein ENSMUSP00000093644
InnateDB Gene IDBG-177700 (Vti1a)
Protein Structure
UniProt Annotation
Function V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with cellular senescence. {ECO:0000269PubMed:19138172}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:9705316}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1855699
InterPro IPR000727 Target SNARE coiled-coil domain
IPR007705 Vesicle transport v-SNARE, N-terminal
IPR010989 t-SNARE
PFAM PF05739
PF05008
PRINTS
PIRSF
SMART SM00397
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O89116
PhosphoSite PhosphoSite-O89116
TrEMBL Q5FWJ7
UniProt Splice Variant
Entrez Gene 53611
UniGene Mm.488719
RefSeq NP_058558
MGI ID 1VCS
MGI Symbol Vti1a
OMIM
CCDS CCDS29910
HPRD
IMGT
EMBL AF035209 AF035823 AK004751 AK028646 BC019386 BC089321 CH466585
GenPept AAC23482 AAC32049 AAH19386 AAH89321 BAB23532 BAC26046 EDL01733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca