InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Naip1

Summary

InnateDB Protein

IDBP-177783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Naip1

Protein Name

NLR family, apoptosis inhibitory protein 1

Synonyms

AV364616; Birc1a; D13Lsd1; Naip; Naip-rs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022142

InnateDB Gene

IDBG-177781 (Naip1)

Protein Structure

UniProt Annotation

Function

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding

Biological Process

GO:0008152	metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071391	cellular response to estrogen stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:1298223

InterPro

IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR007111 NACHT nucleoside triphosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00653

PRINTS

PIRSF

SMART

SM00238

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QWK5