Version 5.4
Mus musculus Protein: Klk1b1
Summary
InnateDB Protein IDBP-177815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klk1b1
Protein Name kallikrein 1-related peptidase b1
Synonyms Klk1; mGK-1; mK1; TK;
Species Mus musculus
Ensembl Protein ENSMUSP00000077879
InnateDB Gene IDBG-177813 (Klk1b1)
Protein Structure
UniProt Annotation
Function Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0002255 tissue kallikrein-kinin cascade
GO:0002936 bradykinin biosynthetic process
GO:0003073 regulation of systemic arterial blood pressure
GO:0003220 left ventricular cardiac muscle tissue morphogenesis
GO:0006508 proteolysis
GO:0042311 vasodilation
GO:0060048 cardiac muscle contraction
Cellular Component
Protein Structure and Domains
PDB ID MGI:892019
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00755
PhosphoSite PhosphoSite-P00755
TrEMBL
UniProt Splice Variant
Entrez Gene 16623
UniGene
RefSeq NP_034775
MGI ID
MGI Symbol Klk1b1
OMIM
CCDS CCDS21190
HPRD
IMGT
EMBL BC026378 J00390 V00829
GenPept AAA39349 AAH26378 CAA24213

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca