InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gc

Summary

InnateDB Protein

IDBP-177827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

group specific component

Synonyms

DBP; VDB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046636

InnateDB Gene

IDBG-177825 (Gc)

Protein Structure

UniProt Annotation

Function

Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0051183	vitamin transporter activity
GO:1902118	calcidiol binding

Biological Process

GO:0042359	vitamin D metabolic process
GO:0051180	vitamin transport

Cellular Component

GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:95669

InterPro

IPR000213 Vitamin D-binding protein
IPR000264 ALB/AFP/VDB
IPR014760 Serum albumin, N-terminal
IPR015247 Vitamin D binding protein, domain III
IPR020858 Serum albumin-like

PFAM

PF00273
PF09164

PRINTS

PR00804
PR00802

PIRSF

SMART

SM00103

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt