InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtf2h2

Summary

InnateDB Protein

IDBP-177875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtf2h2

Protein Name

general transcription factor II H, polypeptide 2

Synonyms

44kDa; BTF2 p44; BTF2-p44; Btf2p44; p44;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065228

InnateDB Gene

IDBG-177873 (Gtf2h2)

Protein Structure

UniProt Annotation

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0008094	DNA-dependent ATPase activity
GO:0008270	zinc ion binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation