InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lonp2

Summary

InnateDB Protein

IDBP-177973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lonp2

Protein Name

lon peptidase 2, peroxisomal

Synonyms

1300002A08Rik; AU015403; Lonp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034141

InnateDB Gene

IDBG-177971 (Lonp2)

Protein Structure

UniProt Annotation

Function

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255HAMAP-Rule:MF_03121}.

Subcellular Localization

Peroxisome matrix {ECO:0000255HAMAP- Rule:MF_03121}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002020	protease binding
GO:0004176	ATP-dependent peptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008233	peptidase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019899	enzyme binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006465	signal peptide processing
GO:0006508	proteolysis
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0006625	protein targeting to peroxisome
GO:0014070	response to organic cyclic compound
GO:0016485	protein processing
GO:0016558	protein import into peroxisome matrix
GO:0031998	regulation of fatty acid beta-oxidation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1914137

InterPro

IPR003111 Peptidase S16, lon N-terminal
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR004815 Lon protease, bacterial/eukaryotic-type
IPR008269 Peptidase S16, Lon C-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR015947 PUA-like domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02190
PF00004
PF07724
PF13304
PF05362
PF07728

PRINTS

PIRSF

PIRSF001174

SMART

SM00464
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt