Version 5.4
Mus musculus Protein: Ankrd17
Summary
InnateDB Protein IDBP-178066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ankrd17
Protein Name ankyrin repeat domain 17
Synonyms 4933425K22Rik; A130069E23Rik; A930008M01; AA407558; AA516750; AU040470; Foe; Gtar; Mask; mKIAA0697;
Species Mus musculus
Ensembl Protein ENSMUSP00000014421
InnateDB Gene IDBG-178064 (Ankrd17)
Protein Structure
UniProt Annotation
Function Earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification. {ECO:0000269PubMed:11165478, ECO:0000269PubMed:11740861}.
Subcellular Localization Cytoplasm. Nucleus. Note=Detected around the nucleolus. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in fetal liver. Detected in adult liver cells, ovarian oocytes, seminiferous tubules of the testes and pelvic region of the kidney. It was not detected in heart, gut, lung, spleen and skeletal muscle. {ECO:0000269PubMed:11165478, ECO:0000269PubMed:11740861}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001955 blood vessel maturation
GO:0007492 endoderm development
GO:0051151 negative regulation of smooth muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1932101
InterPro IPR002110 Ankyrin repeat
IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF00013
PF13014
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99NH0
PhosphoSite PhosphoSite-Q99NH0
TrEMBL
UniProt Splice Variant
Entrez Gene 81702
UniGene Mm.413338
RefSeq NP_112148
MGI ID
MGI Symbol Ankrd17
OMIM
CCDS CCDS57354
HPRD
IMGT
EMBL AC117578 AC162171 AF130371 AK129193 AK160263 AY026253 BC039213 BC057195
GenPept AAH39213 AAH57195 AAK07672 AAQ13559 BAC98003 BAE35720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca