Version 5.4
Mus musculus Protein: Gipc3
Summary
InnateDB Protein IDBP-178098.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gipc3
Protein Name GIPC PDZ domain containing family, member 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000049236
InnateDB Gene IDBG-178096 (Gipc3)
Protein Structure
UniProt Annotation
Function Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. {ECO:0000269PubMed:21326233}.
Subcellular Localization
Disease Associations Note=Defects in GIPC3 underlie the age-related hearing loss 5 (ahl5) and juvenile audiogenic monogenic seizure (jams1) phenotypes. Ahl5 mice show irregular structure of the stereocilia bundle of outer and inner hair cells, late-onset degeneration of the organ of Corti. The spiral ganglion exhibits a severe loss of neurons. {ECO:0000269PubMed:21326233}.
Tissue Specificity Expressed in adult lung, brain and testis. In the inner ear, it is expressed in the inner and outer hair cells of the organ of Corti. Also expressed in cochlear spiral ganglion neurons. {ECO:0000269PubMed:11836631, ECO:0000269PubMed:21326233}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2387006
InterPro IPR001478 PDZ domain
IPR017379 Uncharacterised conserved protein UCP038083, PDZ
PFAM PF00595
PF13180
PRINTS
PIRSF PIRSF038083
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R5M0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 209047
UniGene Mm.218755
RefSeq NP_683753
MGI ID
MGI Symbol Gipc3
OMIM
CCDS CCDS24054
HPRD
IMGT
EMBL AB074494
GenPept BAB84713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca