Version 5.4
| Mus musculus Protein: Klk1b21 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-178101.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Klk1b21 | ||||||||
| Protein Name | kallikrein 1-related peptidase b21 | ||||||||
| Synonyms | Klk21; mGk-21; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000082582 | ||||||||
| InnateDB Gene | IDBG-178099 (Klk1b21) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Displays trypsin-like substrate specificity and shows activity towards casein, gelatin, fibronectin and IGFBP3. {ECO:0000269PubMed:11606460}. | ||||||||
| Subcellular Localization | |||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in testis and submaxillary gland. In the testis, expression localized specifically to Leydig cells in the interstitial tissues. {ECO:0000269PubMed:11606460}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | MGI:892022 | ||||||||
| InterPro |
IPR001254
Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR009003 Trypsin-like cysteine/serine peptidase domain |
||||||||
| PFAM |
PF00089
|
||||||||
| PRINTS |
PR00722
|
||||||||
| PIRSF | |||||||||
| SMART |
SM00020
|
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q61759 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q3UNG6 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 16616 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_034772 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Klk1b21 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS21195 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB039276 AK144221 BC012243 BC145383 CH466603 M18597 M18617 | ||||||||
| GenPept | AAA39359 AAA39360 AAH12243 AAI45384 BAA92319 BAE25781 EDL22696 | ||||||||