InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlk1

Summary

InnateDB Protein

IDBP-178110.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlk1

Protein Name

tousled-like kinase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035961

InnateDB Gene

IDBG-178108 (Tlk1)

Protein Structure

UniProt Annotation

Function

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined. {ECO:0000269PubMed:10523312}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001672	regulation of chromatin assembly or disassembly
GO:0006468	protein phosphorylation
GO:0006886	intracellular protein transport
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0016568	chromatin modification
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2441683

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt