Mus musculus Protein: Hsd3b5 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-178172.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Hsd3b5 | ||||||||||||||
Protein Name | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000041442 | ||||||||||||||
InnateDB Gene | IDBG-178170 (Hsd3b5) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Does not function as a isomerase. | ||||||||||||||
Subcellular Localization | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Expressed in the male liver, starting in late puberty. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:104645 | ||||||||||||||
InterPro |
IPR001509
NAD-dependent epimerase/dehydratase IPR002198 Short-chain dehydrogenase/reductase SDR IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase IPR003869 Polysaccharide biosynthesis protein, CapD-like domain IPR005913 dTDP-4-dehydrorhamnose reductase IPR008030 NmrA-like IPR013120 Male sterility, NAD-binding IPR013968 Polyketide synthase, KR |
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PFAM |
PF01370
PF00106 PF01073 PF02719 PF04321 PF05368 PF07993 PF08659 |
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PRINTS |
PR00080
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PIRSF |
PIRSF000126
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SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q61694 | ||||||||||||||
PhosphoSite | PhosphoSite-Q61694 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 15496 | ||||||||||||||
UniGene | Mm.17910 | ||||||||||||||
RefSeq | NP_032321 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Hsd3b5 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS17666 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC012715 L41519 | ||||||||||||||
GenPept | AAB81242 AAH12715 | ||||||||||||||