Version 5.4
Mus musculus Protein: Nrap
Summary
InnateDB Protein IDBP-178286.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrap
Protein Name nebulin-related anchoring protein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000048364
InnateDB Gene IDBG-178282 (Nrap)
Protein Structure
UniProt Annotation
Function May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000269PubMed:10320340, ECO:0000269PubMed:11732910, ECO:0000269PubMed:9295142}.
Subcellular Localization Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. {ECO:0000269PubMed:11732910, ECO:0000269PubMed:15765519, ECO:0000269PubMed:9295142}.
Disease Associations
Tissue Specificity Expressed in cardiac and skeletal muscle. Not detected in kidney, spleen, liver, brain, lung, stomach or uterus. {ECO:0000269PubMed:11732910, ECO:0000269PubMed:9295142}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017166 vinculin binding
GO:0051371 muscle alpha-actinin binding
Biological Process
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005916 fascia adherens
GO:0005927 muscle tendon junction
GO:0030016 myofibril
Protein Structure and Domains
PDB ID MGI:1098765
InterPro IPR000900 Nebulin repeat
IPR001781 Zinc finger, LIM-type
IPR013998 Nebulin
PFAM PF00880
PF00412
PRINTS PR00510
PIRSF
SMART SM00227
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80XB4
PhosphoSite PhosphoSite-Q80XB4
TrEMBL
UniProt Splice Variant
Entrez Gene 18175
UniGene Mm.469682
RefSeq NP_932307
MGI ID
MGI Symbol Nrap
OMIM
CCDS CCDS29914
HPRD
IMGT
EMBL AC115771 AK138925 AK138975 AY177622 AY177623 U76618
GenPept AAC53323 AAO47075 AAO47076 BAE23819 BAE23843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca