InnateDB Protein
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IDBP-178288.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nrap
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Protein Name
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nebulin-related anchoring protein
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000093640
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InnateDB Gene
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IDBG-178282 (Nrap)
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Protein Structure
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Function |
May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000269PubMed:10320340, ECO:0000269PubMed:11732910, ECO:0000269PubMed:9295142}.
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Subcellular Localization |
Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. {ECO:0000269PubMed:11732910, ECO:0000269PubMed:15765519, ECO:0000269PubMed:9295142}.
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Disease Associations |
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Tissue Specificity |
Expressed in cardiac and skeletal muscle. Not detected in kidney, spleen, liver, brain, lung, stomach or uterus. {ECO:0000269PubMed:11732910, ECO:0000269PubMed:9295142}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1098765
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InterPro |
IPR000900
Nebulin repeat
IPR013998
Nebulin
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PFAM |
PF00880
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PRINTS |
PR00510
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PIRSF |
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SMART |
SM00227
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TIGRFAMs |
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Modification |
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SwissProt |
Q80XB4
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PhosphoSite |
PhosphoSite-Q80XB4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18175
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UniGene |
Mm.469682
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RefSeq |
NP_001273481
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MGI ID |
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MGI Symbol |
Nrap
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC115771
AK138925
AK138975
AY177622
AY177623
U76618
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GenPept |
AAC53323
AAO47075
AAO47076
BAE23819
BAE23843
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