Version 5.4
Mus musculus Protein: Cdca7l
Summary
InnateDB Protein IDBP-178337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdca7l
Protein Name cell division cycle associated 7 like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021592
InnateDB Gene IDBG-178335 (Cdca7l)
Protein Structure
UniProt Annotation
Function Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000250, ECO:0000269PubMed:16829576}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in all tissues but not detected in total brain. {ECO:0000269PubMed:15994933}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2384982
InterPro IPR018866 Zinc-finger domain of monoamine-oxidase A repressor R1
PFAM PF10497
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922M5
PhosphoSite PhosphoSite-Q922M5
TrEMBL
UniProt Splice Variant
Entrez Gene 217946
UniGene Mm.281149
RefSeq NP_666152
MGI ID
MGI Symbol Cdca7l
OMIM
CCDS CCDS49197
HPRD
IMGT
EMBL AK149673 BC006933
GenPept AAH06933 BAE29017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca