Version 5.4
Mus musculus Protein: Slc38a2
Summary
InnateDB Protein IDBP-178367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc38a2
Protein Name solute carrier family 38, member 2
Synonyms 5033402L14Rik; AI316867; ATA2; mKIAA1382; SAT2;
Species Mus musculus
Ensembl Protein ENSMUSP00000023099
InnateDB Gene IDBG-178365 (Slc38a2)
Protein Structure
UniProt Annotation
Function Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. {ECO:0000269PubMed:16365304}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:17003038, ECO:0000269PubMed:17050538}; Multi-pass membrane protein {ECO:0000269PubMed:17003038, ECO:0000269PubMed:17050538}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in cerebral and cerebellar astrocytes and neurons. {ECO:0000269PubMed:12971909}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915010
InterPro IPR013057 Amino acid transporter, transmembrane
PFAM PF01490
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CFE6
PhosphoSite PhosphoSite-Q8CFE6
TrEMBL
UniProt Splice Variant
Entrez Gene 67760
UniGene Mm.474014
RefSeq NP_780330
MGI ID
MGI Symbol Slc38a2
OMIM
CCDS CCDS27778
HPRD
IMGT
EMBL AK031615 AK033812 AK129342 AK169378 BC041108 BC048178 BC049271 BC057454
GenPept AAH41108 AAH48178 AAH49271 AAH57454 BAC27479 BAC28483 BAC98152 BAE41125

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca