Version 5.4
Mus musculus Protein: Cldn14
Summary
InnateDB Protein IDBP-178370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn14
Protein Name claudin 14
Synonyms AI851731;
Species Mus musculus
Ensembl Protein ENSMUSP00000062045
InnateDB Gene IDBG-178368 (Cldn14)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.
Subcellular Localization Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in all sensory epithelia of the inner ear vestibular organs, as well as in liver and kidney. {ECO:0000269PubMed:11163249}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1860425
InterPro IPR003556 Claudin-14
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0S3
PhosphoSite PhosphoSite-Q9Z0S3
TrEMBL A2RSP0
UniProt Splice Variant
Entrez Gene 56173
UniGene Mm.328716
RefSeq NP_062373
MGI ID
MGI Symbol Cldn14
OMIM
CCDS CCDS28345
HPRD
IMGT
EMBL AF124429 AF314089 AK020255 BC132183 BC138497 CH466602
GenPept AAD17323 AAG60051 AAI32184 AAI38498 BAB32041 EDL03752 EDL03753 EDL03754 EDL03755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca