InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sim2

Summary

InnateDB Protein

IDBP-178402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sim2

Protein Name

single-minded homolog 2 (Drosophila)

Synonyms

bHLHe15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072043

InnateDB Gene

IDBG-178400 (Sim2)

Protein Structure

UniProt Annotation

Function

Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00632, ECO:0000255PROSITE-ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Transcripts were detected in high levels in kidney followed by skeletal muscle and lung. Low levels were found in testis, brain and heart. In early fetal development it is found in CNS, developing kidney, tongue epithelium and cartilage primordia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0009880	embryonic pattern specification
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:98307

InterPro

IPR000014 PAS domain
IPR001610 PAC motif
IPR010578 Single-minded, C-terminal
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold

PFAM

PF13188
PF13426
PF06621
PF00010
PF08447
PF00989

PRINTS

PIRSF

SMART

SM00091
SM00086
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61079