InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hlcs

Summary

InnateDB Protein

IDBP-178458.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hlcs

Protein Name

holocarboxylase synthetase (biotin-

Synonyms

410I21.SP6; D16Jhu34;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097112

InnateDB Gene

IDBG-178454 (Hlcs)

Protein Structure

UniProt Annotation

Function

Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity
GO:0004078	biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
GO:0004079	biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
GO:0004080	biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO:0005524	ATP binding
GO:0009374	biotin binding
GO:0018271	biotin-protein ligase activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006464	cellular protein modification process
GO:0008283	cell proliferation
GO:0009305	protein biotinylation
GO:0016570	histone modification
GO:0070781	response to biotin
GO:0071110	histone biotinylation

Cellular Component

GO:0000785	chromatin
GO:0005652	nuclear lamina
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

MGI:894646

InterPro

IPR003142 Biotin protein ligase, C-terminal
IPR004143 Biotin/lipoate A/B protein ligase
IPR004408 Biotin--acetyl-CoA-carboxylase ligase
IPR008988 Transcriptional repressor, C-terminal

PFAM

PF02237
PF03099

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q920N2

PhosphoSite