InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sec13

Summary

InnateDB Protein

IDBP-178464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sec13

Protein Name

SEC13 homolog (S. cerevisiae)

Synonyms

1110003H02Rik; Sec13l1; Sec13r;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032440

InnateDB Gene

IDBG-178462 (Sec13)

Protein Structure

UniProt Annotation

Function

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0015031	protein transport
GO:0051028	mRNA transport

Cellular Component

GO:0000776	kinetochore
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0031080	nuclear pore outer ring
GO:0070062	extracellular vesicular exosome