Version 5.4
Mus musculus Protein: Slc38a4
Summary
InnateDB Protein IDBP-178481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc38a4
Protein Name solute carrier family 38, member 4
Synonyms 1110012E16Rik; 1700012A18Rik; Ata3; mATA3; mNAT3;
Species Mus musculus
Ensembl Protein ENSMUSP00000023101
InnateDB Gene IDBG-178479 (Slc38a4)
Protein Structure
UniProt Annotation
Function Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, His, Gly, Cys, Asn, Thr, Pro, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with lower transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO:0000269PubMed:12537539}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12537539}; Multi-pass membrane protein {ECO:0000269PubMed:12537539}.
Disease Associations
Tissue Specificity Detected in liver, in hepatocytes surrounding the central vein. Not detected in heart, kidney, brain, lung, small intestine, spleen and thymus. {ECO:0000269PubMed:12537539}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006814 sodium ion transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1916604
InterPro IPR013057 Amino acid transporter, transmembrane
PFAM PF01490
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R1S9
PhosphoSite PhosphoSite-Q8R1S9
TrEMBL
UniProt Splice Variant
Entrez Gene 69354
UniGene Mm.413402
RefSeq NP_081328
MGI ID
MGI Symbol Slc38a4
OMIM
CCDS CCDS27779
HPRD
IMGT
EMBL AB055004 AK051023 AK164292 AK167539 AK169349 AY027919 BC024072 BC024123 BC031717
GenPept AAH24072 AAH24123 AAH31717 AAK21967 BAB84091 BAC34500 BAE37721 BAE39606 BAE41099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca