InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amigo2

Summary

InnateDB Protein

IDBP-178560.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amigo2

Protein Name

adhesion molecule with Ig like domain 2

Synonyms

AI415330; Ali1; AMIGO-2; AW208913;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059913

InnateDB Gene

IDBG-178558 (Amigo2)

Protein Structure

UniProt Annotation

Function

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest level in cerebellum, retina, liver, and lung. Lower levels in cerebrum, kidney, small intestine, spleen and testis. {ECO:0000269PubMed:12629050}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0043066	negative regulation of apoptotic process
GO:0043069	negative regulation of programmed cell death

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2145995

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain

PFAM

PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00082
SM00369
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80ZD9