InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clec11a

Summary

InnateDB Protein

IDBP-178585.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clec11a

Protein Name

C-type lectin domain family 11, member a

Synonyms

AW457320; Clecsf3; Scgf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004587

InnateDB Gene

IDBG-178583 (Clec11a)

Protein Structure

UniProt Annotation

Function

Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008083	growth factor activity
GO:0030246	carbohydrate binding

Biological Process

GO:0008284

positive regulation of cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

MGI:1298219

InterPro

IPR001304 C-type lectin
IPR016187 C-type lectin fold

PFAM

PF00059

PRINTS

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88200

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

20256

UniGene

Mm.20428

RefSeq

NP_033157

MGI ID

MGI Symbol

Clec11a

OMIM

CCDS

CCDS21203

HPRD

IMGT

EMBL

AB009245 AK003813 AK042963 BC002001

GenPept

AAH02001 BAA32405 BAB23010 BAC31421