InnateDB Protein
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IDBP-17859.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCP110
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Protein Name
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centriolar coiled coil protein 110kDa
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Synonyms
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Cep110; CP110;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000370803
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InnateDB Gene
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IDBG-17857 (CCP110)
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Protein Structure
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Function |
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. {ECO:0000269PubMed:12361598, ECO:0000269PubMed:16760425, ECO:0000269PubMed:17681131, ECO:0000269PubMed:17719545, ECO:0000269PubMed:23486064}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:12361598, ECO:0000269PubMed:14654843, ECO:0000269PubMed:16760425, ECO:0000269PubMed:17681131, ECO:0000269PubMed:17719545, ECO:0000269PubMed:20596027, ECO:0000269PubMed:21620453}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:12361598}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
50
[view]
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Protein-Protein |
48
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43303
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PhosphoSite |
PhosphoSite-O43303
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9738
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UniGene |
Hs.606159
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RefSeq |
NP_001185951
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HUGO |
HGNC:24342
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OMIM |
609544
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CCDS |
CCDS55992
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HPRD |
10848
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IMGT |
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EMBL |
AB007879
AC003108
AC012621
BC036654
CR749255
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GenPept |
AAC05804
AAH36654
BAA24849
CAH18111
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