Version 5.4
Mus musculus Protein: Cybrd1
Summary
InnateDB Protein IDBP-178594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cybrd1
Protein Name cytochrome b reductase 1
Synonyms 2210407P13Rik; Dcytb;
Species Mus musculus
Ensembl Protein ENSMUSP00000028403
InnateDB Gene IDBG-178592 (Cybrd1)
Protein Structure
UniProt Annotation
Function Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. {ECO:0000269PubMed:11230685, ECO:0000269PubMed:12547225}.
Subcellular Localization Membrane {ECO:0000269PubMed:11230685, ECO:0000269PubMed:12547225}; Multi-pass membrane protein {ECO:0000269PubMed:11230685, ECO:0000269PubMed:12547225}.
Disease Associations
Tissue Specificity Highly expressed in the brush-border membrane of duodenal enterocytes (at protein level). Also expressed in liver and spleen. {ECO:0000269PubMed:11230685, ECO:0000269PubMed:12547225}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000293 ferric-chelate reductase activity
GO:0046872 metal ion binding
Biological Process
GO:0010039 response to iron ion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2654575
InterPro IPR004877 Cytochrome b561, eukaryote
IPR006593 Cytochrome b561/ferric reductase transmembrane
PFAM PF03188
PRINTS
PIRSF
SMART SM00665
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q925G2
PhosphoSite PhosphoSite-Q925G2
TrEMBL Q8K187
UniProt Splice Variant
Entrez Gene 73649
UniGene Mm.45435
RefSeq NP_082869
MGI ID
MGI Symbol Cybrd1
OMIM
CCDS CCDS50603
HPRD
IMGT
EMBL AF354666 AK008849 AK029112 AL929228 BC027665 BC147289 BC147290
GenPept AAH27665 AAI47290 AAI47291 AAK50909 BAB25928 BAC26304 CAM22157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca