Version 5.4
Mus musculus Protein: Cenph
Summary
InnateDB Protein IDBP-178600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenph
Protein Name centromere protein H
Synonyms 1700021I11Rik; 2410018A12Rik; 2610042E16Rik; 2810046K12Rik; AU044255; CENP-H; ENP;
Species Mus musculus
Ensembl Protein ENSMUSP00000074988
InnateDB Gene IDBG-178598 (Cenph)
Protein Structure
UniProt Annotation
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10488063}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:10488063}. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
Disease Associations
Tissue Specificity Abundantly expressed in thymus, spleen, uterus, ovary, testis and muscle, and weakly expressed in small intestine, lung and stomach. Barely detectable expression in kidney, liver, skin and prostate gland. Not detected in brain, heart or adrenal gland. Also expressed weakly in various hematopoietic cell lines. {ECO:0000269PubMed:10488063}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043515 kinetochore binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0051382 kinetochore assembly
GO:0051383 kinetochore organization
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1349448
InterPro IPR008426 Centromere protein H
PFAM PF05837
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QYM8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 26886
UniGene Mm.273502
RefSeq NP_068686
MGI ID
MGI Symbol Cenph
OMIM
CCDS CCDS26738
HPRD
IMGT
EMBL AB017634 AK011264 AK011738 BC025084
GenPept AAH25084 BAA88520 BAB27505 BAB27810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca