Version 5.4
Mus musculus Protein: Gnl3l
Summary
InnateDB Protein IDBP-178626.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnl3l
Protein Name guanine nucleotide binding protein-like 3 (nucleolar)-like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000026297
InnateDB Gene IDBG-178624 (Gnl3l)
Protein Structure
UniProt Annotation
Function Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:21132010}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0015093 ferrous iron transmembrane transporter activity
Biological Process
GO:0006184 GTP catabolic process
GO:0015684 ferrous iron transport
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2448557
InterPro IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01926
PF02421
PRINTS PR00326
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PGG6
PhosphoSite PhosphoSite-Q6PGG6
TrEMBL S4R2Q1
UniProt Splice Variant
Entrez Gene 237107
UniGene Mm.45987
RefSeq NP_001162071
MGI ID
MGI Symbol Gnl3l
OMIM
CCDS CCDS41174
HPRD
IMGT
EMBL AL805937 BC057033 BC079653
GenPept AAH57033 AAH79653 CAM14868

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca