InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncln

Summary

InnateDB Protein

IDBP-178692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncln

Protein Name

nicalin homolog (zebrafish)

Synonyms

3100002P13Rik; AW120537;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020463

InnateDB Gene

IDBG-178690 (Ncln)

Protein Structure

UniProt Annotation

Function

May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0008150	biological_process
GO:0009966	regulation of signal transduction
GO:0016485	protein processing

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1926081

InterPro

IPR007484 Peptidase M28
IPR008710 Nicastrin
IPR016574 Nicalin

PFAM

PF04389
PF05450

PRINTS

PIRSF

PIRSF011018

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VCM8

PhosphoSite

PhosphoSite-Q8VCM8

TrEMBL

UniProt Splice Variant

Entrez Gene

103425

UniGene

Mm.302791

RefSeq

NP_598770

MGI ID

MGI Symbol

Ncln

OMIM

CCDS

CCDS36000

HPRD

IMGT

EMBL

AK019409 AK048954 BC019501

GenPept

AAH19501 BAB31708 BAC33498