Version 5.4
Homo sapiens Protein: SS18
Summary
InnateDB Protein IDBP-1787.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SS18
Protein Name synovial sarcoma translocation, chromosome 18
Synonyms SSXT; SYT;
Species Homo sapiens
Ensembl Protein ENSP00000269137
InnateDB Gene IDBG-1783 (SS18)
Protein Structure
UniProt Annotation
Function Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. {ECO:0000269PubMed:15919756}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
Tissue Specificity Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 38 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007726 SS18 family
PFAM PF05030
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15532
PhosphoSite PhosphoSite-Q15532
TrEMBL Q6FGL9
UniProt Splice Variant
Entrez Gene 6760
UniGene Hs.707065
RefSeq NP_005628
HUGO HGNC:11340
OMIM 600192
CCDS CCDS54183
HPRD 02559
IMGT
EMBL AC091021 AF343880 AK301504 AK304305 AK316302 BC096221 BC096223 BC096224 CH471088 CR542088 CR542103 EF445031 S79894 X79200 X79201
GenPept AAB35674 AAH96221 AAH96223 AAH96224 AAK21314 ACA06073 BAG63015 BAG65158 BAH14673 CAA55792 CAG46885 CAG46900 EAX01209 EAX01210 EAX01213

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca