InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Endou

Summary

InnateDB Protein

IDBP-178727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Endou

Protein Name

endonuclease, polyU-specific

Synonyms

Pp11r; Tcl-30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023105

InnateDB Gene

IDBG-178723 (Endou)

Protein Structure

UniProt Annotation

Function

Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Specifically expressed in T-cells during apoptosis. Expressed in surface heat stable antigen (HSA)- containing T-cells populations (CD4(-)CD8(-)HSA(+), CD4(+)CD8(-)HSA(+), CD4(-)CD8(+)HSA(+), and CD4(+)CD8(+)HSA(+)) and not in the HSA(-) single positive T-cell populations of the thymus or spleen, suggesting that expression is lost during T-cell maturation and is absent at the most mature stages of T-cell development. {ECO:0000269PubMed:1506680, ECO:0000269PubMed:8104059}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004521	endoribonuclease activity
GO:0005044	scavenger receptor activity
GO:0008236	serine-type peptidase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0030247	polysaccharide binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0007565	female pregnancy
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic